NuCalm® is clinically proven to naturally relax the brain and body within minutes, without drugs.

This patented, clinically-proven neuroscience technology addresses the brain circuitry in the limbic system, the hypothalamus and the brainstem responsible for activating the stress response. NuCalm works specifically on the body’s inhibitory system, the vagus nerve and the GABAergic system. NuCalm is comprised of three steps that work together to guide brain waves into alpha and theta (just above deep sleep) to create cellular restoration and parasympathetic nervous system dominance. Within moments, you will begin to feel relief from the ‘fight-or-flight’ sympathetic nervous system response and your stress hormone (cortisol) levels will begin to decline as the stress response (HPA axis) is inhibited.

The Physiology of the Human Stress Response

The Physiology of the Human Stress Response

When a stressor is perceived by the amygdala, it contacts an array of brain regions using neurotransmitters called corticotropin releasing hormone (CRH). One set of nerve cells projecting from the amygdala reaches parts of the midbrain and brain stem. These structures control the autonomic nervous system, the network of nerve cells projecting to parts of the body that function involuntarily (heart rate, breathing, sweating, etc.). Half of the autonomic nervous system is the sympathetic nervous system (SNS), which modulates fight-or-flight. Once the amygdala is activated, the sympathetic nervous system directs the adrenal glands to secrete epinephrine via the HPA Axis. The HPA Axis is comprised of the hypothalamus communicating to the pituitary gland communicating to the adrenal glands. Epinephrine impacts the body’s physiology, resulting in an increased heart rate, shallow breathing, and hypervigilant senses. Epinephrine mobilizes energy for muscles, increases cardiovascular tone so oxygen can travel more rapidly, and turns off non-essential activities like growth. Interestingly, the HPA Axis is a one-way communication channel. Therefore, once a person’s fight-or-flight response is activated, there is no turning back. The body is now focused exclusively on fighting or fleeing from the stressor, and the mind cannot rationalize or self-regulate until after the threat is removed and time passes. The human stress response is a perfect system of neuronal circuitry that has evolved for millions of years and triggers the fight-or-flight response every single time your limbic system perceives a threat. This system is designed exclusively for survival. The challenge humans experience today is that this system is triggered when our lives are not at risk. This disconnect negatively impacts the autonomic nervous system – the system that manages fear, stress, and anxiety, and results in people living “on edge.”

The Negative Impact Of Stress

Stress causes chemical and structural changes in every system in the body:

Nervous System

Development of tumors, cerebral hemorrhages, aneurysms, strokes,
dementia, cognitive impairment, depression, memory loss

Circulatory System

Constricts arterial system, promotes cardiovascular disease, causes blood pressure and heart rate changes

Endocrine System

Release of cortisol and ACTH which stimulates adrenal cortex, exhausts adrenal glands, thyroid malfunction, weight gain, can cause diabetes, decreases immune cell count, can lead to cancer

Digestive System

Nervous stomach, nausea, bleeding ulcers, spastic colon, ulcerative colitis

A Big Solution To A Big Problem

Avoiding the midbrain hijack is not a “mind-over-matter” challenge. It’s a much bigger challenge. The limbic system (midbrain region responsible for survival) is over 40 million years evolved. Your frontal lobe (responsible for rational function, behavior control, and emotional regulation) has evolved for over 4 million years. Simply put, your midbrain has a 36-million-year head-start and is superior when it comes to acquiring resources and redirecting biological function when it gets triggered. So, you need to overcome your primitive survival function and refined limbic system to manage stress on your terms. What if there was a way to naturally interrupt the HPA Axis and stop the chemical reaction triggered by your fight-or-flight response?

Research and Innovation

Research and Innovation

Dr. Holloway spent over four decades treating people suffering from acute Post-Traumatic Stress Disorder (PTSD) who often self-medicated with drugs and alcohol. He understood the negative consequences of allowing PTSD to go untreated and how drugs and alcohol may provide short-term relief; however, they have severe negative consequences over time.

To develop a solution that organically diffused the stress response, Dr. Holloway took a systematic approach to the chemical reaction of stress. Over a twenty-year period, Dr. Holloway developed the NuCalm system by using biochemistry and physics to naturally interrupt the stress response and induce parasympathetic nervous system dominance.

 The NuCalm Solution

The NuCalm Solution

NuCalm solves the riddle of safely and reliably managing stress. NuCalm is the world’s first and only patented neuroscience clinically proven to reduce stress and improve sleep quality without drugs. NuCalm uses state-of-the-art applied neuropsychobiology and neurobioinformatics to mimic the body’s natural experience of slowing brain and body function in preparation for sleep.
NuCalm guides your brain wave function to alpha and theta ranges and suspends you in parasympathetic nervous system dominance – a state of relaxation where you are physically incapable of experiencing stress.

NuCalm's Systematic Approach

NuCalm is comprised of three components that work together to rapidly reduce the adrenaline response in your brain and guide your mind and body to a deeply relaxed state.

NuCalm Product

NuCalm Light-Blocking Eye Mask
Blocks visual stimulation and maintains the relaxed state.

NuCalm Biosignal Processing Disc
All cells of the human body communicate through frequencies. The NuCalm biosignal processing disc delivers the biological signals your body needs to slow down brain activity and prepare for relaxation. This mimics your body’s normal transition from action to idleness and sleep preparation. The NuCalm biosignal processing disc enables the neuroacoustic software to work at maximum efficiency.

NuCalm Neuroacoustic Software
Patented neuroacoustic software that uses binaural signal processing, frequency-following-response neurobiofeedback, and complex vibration, resonance, and harmonic oscillations to create resonant frequencies in the alpha and theta frequency ranges (12Hz-4Hz) – where recovery and restoration naturally occur.